Synthesis and pharmacological activities of some new 2-[1-(6-methoxy-2-naphthyl)ethyl]-6-(substituted)benzylidene thiazolo[3,2-b]-1,2,4-triazole-5(6H)one derivatives

Authors
Berk, B Aktay, G Yesilada, E Ertan, M
Citation
B. Berk et al., Synthesis and pharmacological activities of some new 2-[1-(6-methoxy-2-naphthyl)ethyl]-6-(substituted)benzylidene thiazolo[3,2-b]-1,2,4-triazole-5(6H)one derivatives, PHARMAZIE, 56(8), 2001, pp. 613-616
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
56
Issue
8
Year of publication
2001
Pages
613 - 616
Database
ISI
SICI code
0031-7144(200108)56:8<613:SAPAOS>2.0.ZU;2-Q
Abstract
In this study, thirteen new compounds having a 2-[1-(6-methoxy-2-naphthyl)e thyl]-6-(substituted)benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-one st ructure were synthesised using N-[2-(6-methoxy-2-naphthyl)propanoyloxysucci nimide, N-[2(6-methoxy-2-naphthyl)propanoyl]thiosemicarbazide and 3-[1-(6-m ethoxy-2-naphthyl)ethyl]-5-mercapto-1,2,4-triazole. The structures and phys ical properties of the compounds were elucidated by IR, H-1 NMR, mass spect roscopy and elemental analysis. The antiinflammatory activity and gastric u lceration potential of the compounds were tested using naproxen as a refere nce compound.