Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry

The electrochemical oxidation of olsalazine sodium was investigated by cycl ic, linear sweep, differential pulse and square wave voltammetry using glas sy carbon disc electrode in different buffer systems. Best results were obt ained for the determination of olsalazine using the differential pulse volt ammetric technique in phosphate buffer at pH 7.0. The electroactive species exhibits a diffusion-controlled voltammetric wave and its differential pul se peak current shows a linear dependence on olsalazine concentration in th e range between 2 x 10(-6) M and 2 x 10(-4) M. This relationship has been a pplied to (lie determination of olsalazine in commercial capsule dosage for ms. The recovery study shows good accuracy and precision for the assay deve loped. A UV spectrophotometric assay is also reported for comparison.