Evaluation of the antidiabetic action of Mangifera indica in mice

The leaves of Mangifera indica were assessed for antidiabetic properties us ing normoglycaemic, glucose-induced hyperglycaemia and streptozotocin (STZ) induced diabetic mice. The aqueous extract produced a reduction of blood g lucose level in normoglycaemic and glucose-induced hyperglycaemia, but did not have any effect on streptozotocin-induced diabetic mice. The hypoglycae mic effect of the aqueous extract was compared with that of an oral dose of chlorpropamide under the same conditions. The results of this study indica te that the aqueous extract of the leaves of Mangifera indica possess hypog lycaemic activity. Copyright (C) 2001 John Wiley & Sons, Ltd.