A novel tool for the prediction of transmembrane protein topology based ona statistical analysis of the SwissProt database: the OrienTM algorithm

OrienTM is a computer software that utilizes an initial definition of trans membrane segments to predict the topology of transmembrane proteins from th eir sequence. It uses position-specific statistical information for amino a cid residues which belong to putative non-transmembrane segments derived fr om statistical analysis of non-transmembrane regions of membrane proteins s tored in the SwissProt database. Its accuracy compares well with that of ot her popular existing methods. A web-based version of OrienTM is publicly av ailable at the address http://biophysics.biol.uoa.gr/OrienTM.