Recent research suggests that stress, anxiety, and depression during pregna
ncy may have an impact on how the child develops. In this article, the cent
ral literature supporting this hypothesis is reviewed. Next, studies from o
ur laboratory showing that differences in fetal heart rate patterns are ass
ociated with women's anxiety and depressive symptomatology are reviewed. Th
e data indicate that we can detect fetal markers associated with alteration
s in women's mood that also are linked to differences in the neurobiologica
l substrate of the fetus' emerging emotion regulation system. Identifying s
uch fetal characteristics someday may contribute to the early detection and
prevention of predispositions to childhood risk for emotional problems and
even psychopatholgy.