Disproportionately severe calcinosis cutis in an 88-year-old patient with CREST syndrome

An 88-year-old woman with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias) presented with hyperglycemia, intravascular depletion, and atrial fibrillation. The patie nt was found to have unusually severe calcinosis cutis in both legs extendi ng from the knees to the ankles bilaterally, as well as Raynaud's phenomeno n, sclerodactyly, and telangiectasias. The patient was normocalcemic and no rmophosphatemic. Although subcutaneous calcification is often seen with CRE ST syndrome, this case is unusual in that the area of involvement was much larger than previously described. Furthermore, the amount of calcinosis was disproportionately severe and was the major cause of symptoms and disabili ty compared with the other components of the syndrome.