Regiospecific cyclization of beta-methoxyvinyl trifluoromethyl ketones with aminoguanidine: A convenient method to obtain trifluoromethylated 2-[1H-pyrazol-1-yl]pyrimidines

Authors
Bonacorso, HG Wentz, AP Zanatta, N Martins, MAP
Citation
Hg. Bonacorso et al., Regiospecific cyclization of beta-methoxyvinyl trifluoromethyl ketones with aminoguanidine: A convenient method to obtain trifluoromethylated 2-[1H-pyrazol-1-yl]pyrimidines, SYNTHESIS-S, (10), 2001, pp. 1505-1508
Citations number
25
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
10
Year of publication
2001
Pages
1505 - 1508
Database
ISI
SICI code
0039-7881(200108):10<1505:RCOBTK>2.0.ZU;2-N
Abstract
The regiospecific one-pot synthesis of a novel series of 6-alkyl(aryl)-2-[3 -alkyl(aryl)-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl]-4-tri fluoromethylpyrimidines 2 and 6-alkyl(aryl)-2-[3-alkyl(aryl)-5-trifluoromet hyl-1H-pyrazol-1-yl]-4-trifluoromethylpyrimidines 3 from 4-alkyl(aryl)-1,1, 1-trifluoro-4-methoxyalk-3-en-2-ones I and aminoguanidine bicarbonate is re ported.