6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione: a novel method of pyrrole-ring annulation to an azine nucleus based on a tandem S-N(H)-S-N(H)process
Av. Gulevskaya et al., 6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione: a novel method of pyrrole-ring annulation to an azine nucleus based on a tandem S-N(H)-S-N(H)process, TETRAHEDR L, 42(34), 2001, pp. 5981-5983
6,8-Dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione has been shown to re
act with some secondary amines in the presence of an oxidant to produce 6,8
-dimethylpyrrolo[2 ' ,3 ' ;3,4]pyridazino[6,5-d]pyrimidine-7,9(6H,SH)-dione
derivatives. The reaction represents a new method of pyrrole-ring annulati
on to an azine nucleus via a tandem S-N(H)-S-N(H) process. (C) 2001 Elsevie
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