6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione: a novel method of pyrrole-ring annulation to an azine nucleus based on a tandem S-N(H)-S-N(H)process

Authors
Gulevskaya, AV Besedin, DV Pozharskii, AF Starikova, ZA
Citation
Av. Gulevskaya et al., 6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione: a novel method of pyrrole-ring annulation to an azine nucleus based on a tandem S-N(H)-S-N(H)process, TETRAHEDR L, 42(34), 2001, pp. 5981-5983
Citations number
7
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
34
Year of publication
2001
Pages
5981 - 5983
Database
ISI
SICI code
0040-4039(20010820)42:34<5981:6ANMOP>2.0.ZU;2-T
Abstract
6,8-Dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione has been shown to re act with some secondary amines in the presence of an oxidant to produce 6,8 -dimethylpyrrolo[2 ' ,3 ' ;3,4]pyridazino[6,5-d]pyrimidine-7,9(6H,SH)-dione derivatives. The reaction represents a new method of pyrrole-ring annulati on to an azine nucleus via a tandem S-N(H)-S-N(H) process. (C) 2001 Elsevie r Science Ltd. All rights reserved.