Reversal of enantioselectivity using catalysts containing multiple stereogenic centres

Authors
Cobb, AJA Marson, CM
Citation
Aja. Cobb et Cm. Marson, Reversal of enantioselectivity using catalysts containing multiple stereogenic centres, TETRAHEDR-A, 12(11), 2001, pp. 1547-1550
Citations number
27
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
11
Year of publication
2001
Pages
1547 - 1550
Database
ISI
SICI code
0957-4166(20010704)12:11<1547:ROEUCC>2.0.ZU;2-I
Abstract
N-methylation of ligands with multiple stereogenic centres is shown to prov ide the product of the opposite configuration in significant enantiomeric e xcess (e.e), in the addition of diethylzinc to aldehydes. The catalysts pos sess stereogenic centres appended to a trans-1,2-cyclohexanediamine core. ( C) 2001 Elsevier Science Ltd. All rights reserved.