Synthesis of new chiral Schiff bases and their application in the asymmetric trimethylsilylcyanation of aromatic aldehydes

Authors
Yang, ZH Wang, LX Zhou, ZH Zhou, QL Tang, CC
Citation
Zh. Yang et al., Synthesis of new chiral Schiff bases and their application in the asymmetric trimethylsilylcyanation of aromatic aldehydes, TETRAHEDR-A, 12(11), 2001, pp. 1579-1582
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
11
Year of publication
2001
Pages
1579 - 1582
Database
ISI
SICI code
0957-4166(20010704)12:11<1579:SONCSB>2.0.ZU;2-1
Abstract
The new chiral Schiff base ligands 1a-1c were synthesized from (1R)-(+)-cam phor and found to be efficient catalysts for the enantioselective silylcyan ation of aromatic aldehydes. The corresponding aromatic cyanohydrins were o btained in good yields and with enantiomeric excesses (e.e.s) of up to 73%. (C) 2001 Elsevier Science Ltd. All rights reserved.