The apparent success in vector control observed between 1950 and 1970 was f
ollowed by worldwide resistance to organosynthetic insecticides wherever th
ey were used intensively. Insect resistance to one or more categories of in
secticides has limited the effectiveness of these compounds, and their nons
elective mode of action adversely affects non-target organisms. This scenar
io highlights the need for selective agents in integrated vector control pr
ograms. This article gives an overview of the main fundamental and applied
research topics on entomopathogenic bacteria in relation to their role in v
ector control.