CLONAL CHROMOSOME-ABERRATIONS WITH MONOSOMY OF CHROMOSOME-8 IN A CASEOF GRADE-III CHONDROSARCOMA

Authors
PTASZYNSKI K RAMESH KH CANNIZZARO LA
Citation
K. Ptaszynski et al., CLONAL CHROMOSOME-ABERRATIONS WITH MONOSOMY OF CHROMOSOME-8 IN A CASEOF GRADE-III CHONDROSARCOMA, Cancer genetics and cytogenetics, 97(1), 1997, pp. 60-63
Citations number
16
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
97
Issue
1
Year of publication
1997
Pages
60 - 63
Database
ISI
SICI code
0165-4608(1997)97:1<60:CCWMOC>2.0.ZU;2-N
Abstract
We report cytogenetic findings in a case of grade III chondrosarcoma. Complex clonal chromosome aberrations including monosomy of chromosome s 4, 8, 13, and a consistent t(5;14)(q23;p12) were observed in all cel ls. There were no structural or numerical anomalies involving chromoso me 12. The complexity of the chromosome aberrations reflect the advanc ed stage of this chondrosarcoma; we suggest a possible involvement of the EXT1 gene located on chromosome 8. (C) 1997 Elsevier Science Inc., 1997.