Study of 2708 heroin-related deaths in north-eastern Italy 1985-98 to establish the main causes of death

Aims. To ascertain the causes of deaths among a very large cohort of heroin injecting drug users (IDUs) who, from 1985 to 1998, attended 36 Public Hea lth Authority Centres for Drug Users (PCDUs) in north-eastern Italy. Design . Retrospective analysis of data, obtained from the Annual Register of each Centre and the Municipal Registry Office of each local health district. Se tting. Thirty-six PCDUs in north-eastern Italy and Medical Service for Addi ctive Disorders of the University of Verona. Participants. All IDUs who had sought medical care at least once in the PCDUs during the study period. Fi ndings. Of 2708 deaths, overdose was found to be the major cause (37%), fol lowed by AIDS (32.5%) and road accidents (9.4%). The percentage of deaths d ue to AIDS increased steadily from 2.7% in 1985 to 42.2% in 1996, and then decreased to 16.9% in 1998. Deaths due to overdose remained almost constant . The average age of death per year rose from 26 in the mid eighties to 34 in 1998. The mortality rate among IDUs proved much higher compared to the g eneral population of the same age (13-fold, 95% CI, 11.3-14.6). The proport ion of all deaths attributable to regular use of illegal opiates in the 15- 34 age group in the general population in 1991 was 16%. HIV prevalence was not a significant factor in suicides and deaths by overdose. Conclusions. T he mortality rate was 13 times greater than in the general population. To b e female and to have dropped out of any kind of treatment proved an importa nt risk factor for overdose. The fall in deaths from AIDS enhances the prob lem to prevent and treat HCV infection. Decisions in drug projects, in rese arch and in training should be influenced by the strikingly high percentage of deaths due to drug use.