Fungemia in HIV-infected patients: A 12-year study in a tertiary care hospital

Opportunistic infections caused by fungi are common in human immunodeficien cy virus (HIV)-infected patients. We focused on severe infections as indica ted by detectable fungemia. Medical charts available for patients having po sitive blood cultures with fungi at the University of Geneva Hospital were retrospectively (1989 to 2000) reviewed. Of 328 patients with fungemia duri ng the study period, 315 (96%) medical charts were accessible. Of these 315 patients, 37 (12.2%) were HIV-positive, and 13 (35.1%) died within 6 month s from their episode of fungemia. This was a lower mortality rate than for the HIV seronegative patients (45.8%). The median and average age of the 34 HIV-positive patients was 37.2 years, and 24 (64.9%) were males. Cryptococ cus neoformans (n=14) and Candida albicans (n=12) were the most frequently identified species, followed by Candida glabrata (n=3), of which 3 were mix ed C. albicans + C. glabrata, Histoplasma capsulatum (n=2), and Penicillium marneffei (n=2). The frequency decreased significantly (p<0.007) from the time period 1993 to 1996 (n=21) to the period 1997 to 2000 (n=6). Fungemias in HIV-infected patients have declined significantly since 1996. This coin cides with the introduction of highly active antiretroviral therapy (HAART) .