Effect of rosuvastatin on low-density lipoprotein cholesterol in patients with hypercholesterolemia

Rosuvastatin is a new, synthetic, orally active statin, with marked low-den sity lipoprotein (LDL) cholesterol-lowering activity. We conducted 2 dose-r anging studies. In the first study, after a 6-week dietary run-in, 142 mode rately hypercholesterolemic patients were randomized equally to receive dou ble-blind placebo or rosuvastatin 1, 2.5, 5, 10, 20, or 40 mg or open-label atorvastatin 10 or 80 mg once daily for 6 weeks; in the second study, cond ucted to extend the rosuvastatin dose range, 64 patients were randomized to double-blind, once-daily placebo or rosuvastatin 40 or 80 mg (1: 1:2 ratio ) for 6 weeks. Data from both studies were combined for analysis of lipid e ffects. No statistical comparison of atorvastatin arms with placebo or rosu vastatin was performed. Rosuvastatin was associated with highly significant dose-dependent reductions in LDL cholesterol compared with placebo (p < 0. 001); decreases ranged from 34% (1 mg) to 65% (80 mg). Linear regression an alysis indicated an additional 4.5% LDL cholesterol reduction for each doub ling of the rosuvastatin dose. Across the dose range, approximately 90% of LDL cholesterol reduction occurred within the first 2 weeks of treatment. S ignificant, dose-dependent reductions in total cholesterol and apolipoprote in B with rosuvastatin were also observed (p <0.001). High-density lipoprot ein cholesterol increases and triglyceride reductions were consistently obs erved and statistically significant at some dose levels. All lipid ratios w ere significantly reduced at all rosuvastatin dose levels (p <0.001). Adver se events were similar across placebo and active treatments. No significant increases in alanine aminotransferase or creatine kinase were seen in any patient. Over 6 weeks, rosuvastatin produced large, rapid, dose-dependent L DL cholesterol reductions and was well tolerated in hypercholesterolemic pa tients. <(c)> 2001 by Excerpta Medica, Inc.