Electrical activity of the diaphragm during pressure support ventilation in acute respiratory failure

We compared crural diaphragm electrical activity (EAdi) with transdiaphragm atic pressure (Pdi) during varying levels of pressure support ventilation ( PS) in 13 intubated patients. With changing PS, we found no evidence for ch anges in neuromechanical coupling of the diaphragm. From lowest to highest PS (2 cm H2O +/- 4 to 20 cm H2O +/- 7), tidal volume increased from 430 ml 180 to 527 ml 180 (p < 0.001). The inspiratory volume calculated during the period when EAdi increased to its peak did not change from 276 +/- 147 to 277 +/- 162 ml, p = 0.976. Respiratory rate decreased from 23.9 (+/-7) to 2 1.3 (+/-7) breaths/min (p = 0.015). EAdi and Pdi decreased proportionally b y adding PS (r = 0.84 and r = 0.90, for mean and peak values, respectively) . Mean and peak EAdi decreased (p < 0.001) by 33 +/- 21% (mean +/- SD) and 37 +/- 23% with the addition of 10 cm H2O Of PS, Similar to the decrease in the mean and peak Pdi (p < 0.001) observed (34 <plus/minus> 36 and 35 +/- 23%). We also found that ventilator assist continued during the diaphragm d eactivation period, a phenomenon that was further exaggerated at higher PS levels. We conclude that EAdi is a valid measurement of neural drive to the diaphragm in acute respiratory failure.