F. Ouenadio et al., Synthesis and antiproliferative activity of [2-(phthaloylamino)alkyl]triphenyl phosphonium derivatives against K562 cell line, ANTI-CANC D, 12(7), 2001, pp. 603-606
Given the reported cytotoxicity of phthaloylaminoethyltriphenylphosphonium
bromide 2a in the P-388 cell line, we have developed new [2-(phthaloylamino
)alkyl]phosphonium derivatives 2b-e and evaluated their cytotoxic activity.
These compounds have been synthetized from N,N-phthaloylaminoalcohols and
triphenylphosphonium hydrobromide via a one-pot reaction. 2a was found inac
tive in the K562 cell line, but 2c-e exhibited a cytotoxic activity with IC
50 values about 1 muM. [(C) 2001 Lippincott Williams & Wilkins.].