A case of glassy cell carcinoma of the uterine cervix effectively responding to chemotherapy with paclitaxel and carboplatin

Glassy cell carcinoma (GCC) of the uterine cervix is a highly malignant tum or and has a poor prognosis. As yet, no effective systemic chemotherapy to this tumor has been reported. Here we describe a case of recurrent GCC that responded to paclitaxel and carboplatin combination treatment. The patient , a 32-year-old woman, with clinical staging FIGO IB1 disease had a radical hysterectomy and postoperative radiotherapy. Three months after initial tr eatment, she had a relapse as peritoneal dissemination, which was confirmed in the second surgery (adnectomy) and which did not respond to platinum-ba sed conventional chemotherapy (cisplatin, adriamycin, cyclophosphamide and carboplatin, etoposide). The recurrent peritoneal tumors responded well to paclitaxel and carboplatin combination treatment. An elevated serum concent ration of carcinoembryonic antigen (672 ng/ml) was reduced to 14.4 ng/ml by six such courses. Peritonea[ histopathology confirmed a complete response in the third surgery (ileostomy) for adhesive ileus by the radiotherapy. Th is Is the first report of effective systemic chemotherapy with paclitaxel a nd carboplatin to recurrent GCC of the uterine cervix. [(C) 2001 Lippincott Williams & Wilkins.].