Am. Smith et al., Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility, ANTIM AG CH, 45(9), 2001, pp. 2648-2650
We report two South African serotype 6B pneumococcal isolates with cephalos
porin resistance, yet with susceptibility to penicillin. DNA fingerprinting
revealed that they were clonal in origin. pbp 2X and 1A genes showed major
alterations typical of cephalosporin-resistant pneumococci. The pbp 2B gen
e was completely unaltered, explaining the penicillin susceptibility of the
isolates.