Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility

Authors
Smith, AM Botha, RF Koornhof, HJ Klugman, KP
Citation
Am. Smith et al., Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility, ANTIM AG CH, 45(9), 2001, pp. 2648-2650
Citations number
17
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
9
Year of publication
2001
Pages
2648 - 2650
Database
ISI
SICI code
0066-4804(200109)45:9<2648:EOAPCW>2.0.ZU;2-X
Abstract
We report two South African serotype 6B pneumococcal isolates with cephalos porin resistance, yet with susceptibility to penicillin. DNA fingerprinting revealed that they were clonal in origin. pbp 2X and 1A genes showed major alterations typical of cephalosporin-resistant pneumococci. The pbp 2B gen e was completely unaltered, explaining the penicillin susceptibility of the isolates.