The production of F-18-fluoride from a gas target which utilizes the O-18(p
,n)F-18 reaction is described. Proof-of-principle experiments demonstrate t
hat it is possible to design and build such a target that can be used routi
nely to produce terabecquerel (curie) quantities of F-18 when operated at 1
00 muA. (C) 2001 Elsevier Science Ltd. All rights reserved.