HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum

Authors
Kim, HJ Woo, ER Shin, CG Hwang, DJ Park, H Lee, YS
Citation
Hj. Kim et al., HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum, ARCH PH RES, 24(4), 2001, pp. 286-291
Citations number
22
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
24
Issue
4
Year of publication
2001
Pages
286 - 291
Database
ISI
SICI code
0253-6269(200108)24:4<286:HIIPGF>2.0.ZU;2-V
Abstract
Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside ( 6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Com pounds 1 and 2 showed potent inhibitory activities against HIV-1 integrase with IC50 values of 7.8 +/- 3.6 and 13.7 +/- 6.0 muM, respectively.