Jm. Labaune et al., Once-a-day individualized amikacin dosing for suspected infection at birthbased on population pharmacokinetic models, BIOL NEONAT, 80(2), 2001, pp. 142-147
Amikacin is widely used in the treatment of suspected or confirmed neonatal
infections. However, dosage regimens are not well defined in this group of
patients because of a wide inter-individual pharmacokinetic variability. A
n individualized goal-oriented amikacin dosage design was applied using pop
ulation pharmacokinetic data. A dosing chart was developed for neonates dur
ing the first 2 days of life, by using population pharmacokinetic parameter
values and USCPACK software. This dosing chart based on gestational age (G
A) and body weight gives a once-a-day amikacin dosage regimen involving an
injection every 24 h. Validation was performed in 57 neonates less than 2 d
ays old, divided into three GA groups and prospectively treated using the d
osing chart. Target peak serum levels of amikacin were obtained in 62-80% o
f patients after the first dose and in 80-100% after the second dose, and t
rough concentrations were obtained in 100%. This study has confirmed the ne
ed for individualization of amikacin dosage regimens in neonates. Copyright
(C) 2001 S. Karger AG, Basel.