Pre- and postnatal tissue selenium of the rat in the growing state

The aim of this study is to quantify the selenium (Se)content (in mug/g) du ring different gestational periods in rat fetal tissues, and to follow up t he changes in the Se content of the placenta, fetal head, liver and lung du ring gestation and postpartum periods. Locally reared virgin female Wistar rats were mated. Pregnant rats were sacrificed on days 15, 18 and 21 of pre gnancy. Newborn pups at the age of 3 days and rats at the age of 1 month we re also investigated. There was a gradual increase in placental and whole h ead Se content as gestation proceeded compared to day 15; however, the diff erences between the groups were not statistically significant. The liver Se content at day 18 of gestation was significantly higher than at day 21 of gestation and in rats at 3 days of age, but lower than the Se content of th e liver of rats at the age of 1 month and the differences were statisticall y significant. The lung Se content was higher at day 18 of gestation than a t day 21 and in the 3-day-old rats, and all differences between all groups were statistically significant except when the lung Se content at day 18 is compared to that of 1-month-old animals. The continuous increase in the Se content of the placental tissues and the whole head, although not signific ant statistically, may indicate that the fetus relies heavily on its supply of Se from the maternal blood and in part on the supply of thyroid hormone s which are important for brain development, as evidence exists that T-4 an d T-3 are present in the fetal brain in early fetal life before the onset o f fetal thyroid function. The higher content of Se on day 18 and its declin e on day 21 of gestation in the liver may imply that it is stored and being utilized partly in other tissues for other functions and particularly for thyroid hormone synthesis, metabolism and functions. Copyright (C) 2001 S. Karger AG, Basel.