Evolution of anti-HIV drug candidates part 2: Diaryltriazine (DATA) analogues

Authors
Ludovici, DW Kavash, RW Kukla, MJ Ho, CY Ye, H De Corte, BL Andries, K de Bethune, MP Azijn, H Pauwels, R Moereels, HEL Heeres, J Koymans, LMH de Jonge, MR Van Aken, KJA Daeyaert, FFD Lewi, PJ Das, K Arnold, E Janssen, PAJ
Citation
Dw. Ludovici et al., Evolution of anti-HIV drug candidates part 2: Diaryltriazine (DATA) analogues, BIOORG MED, 11(17), 2001, pp. 2229-2234
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
17
Year of publication
2001
Pages
2229 - 2234
Database
ISI
SICI code
0960-894X(20010903)11:17<2229:EOADCP>2.0.ZU;2-A
Abstract
A synthesis program directed toward improving the stability of imidoyl thio urea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described. (C) 2001 Elsevier Science Ltd. Al l rights reserved.