Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues

Authors
Ludovici, DW De Corte, BL Kukla, MJ Ye, H Ho, CY Lichtenstein, MA Kavash, RW Andries, K de Bethune, MP Azijn, H Pauwels, R Lewi, PJ Heeres, J Koymans, LMH de Jonge, MR Van Aken, KJA Daeyaert, FFD Das, K Arnold, E Janssen, PAJ
Citation
Dw. Ludovici et al., Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues, BIOORG MED, 11(17), 2001, pp. 2235-2239
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
17
Year of publication
2001
Pages
2235 - 2239
Database
ISI
SICI code
0960-894X(20010903)11:17<2235:EOADCP>2.0.ZU;2-B
Abstract
The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAP Ys) are described. Several members of this novel class of non-nucleoside re verse transcriptase inhibitors (NNRTIs) are extremely potent against both w ild-type and a panel of clinically significant single- and double-mutant st rains of HIV-1. (C) 2001 Elsevier Science Ltd. All rights reserved.