Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents

Authors
Seefeld, MA Miller, WH Newlander, KA Burgess, WJ Payne, DJ Rittenhouse, SF Moore, TD DeWolf, WE Keller, PM Qiu, XY Janson, CA Vaidya, K Fosberry, AP Smyth, MG Jaworski, DD Slater-Radosti, C Huffman, WF
Citation
Ma. Seefeld et al., Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents, BIOORG MED, 11(17), 2001, pp. 2241-2244
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
17
Year of publication
2001
Pages
2241 - 2244
Database
ISI
SICI code
0960-894X(20010903)11:17<2241:IOBEAC>2.0.ZU;2-8
Abstract
An SAR study of a screening lead has led to the identification of 2,9-disub stituted 1, 2, 3, 4-tetrahydropyrido [3,4-b]indoles as inhibitors of Staphy lococcus aureus enoyl acyl carrier protein reductase (FabI). (C) 2001 Elsev ier Science Ltd. All rights reserved.