Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors

Authors
Dener, JM Wang, VR Rice, KD Gangloff, AR Kuo, EYL Newcomb, WS Putnam, D Wong, M
Citation
Jm. Dener et al., Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors, BIOORG MED, 11(17), 2001, pp. 2325-2330
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
17
Year of publication
2001
Pages
2325 - 2330
Database
ISI
SICI code
0960-894X(20010903)11:17<2325:MIOMCT>2.0.ZU;2-7
Abstract
Truncation of potent and selective dibasic inhibitors afforded monocharged inhibitors of human mast-cell tryptase. Using two classes of analogues as l ead structures, several monocharged derivatives were identified with Ki val ues ranging front 0.084 to 0.21 muM against the enzyme. (C) 2001 Elsevier S cience Ltd. All rights reserved.