New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D-2-receptor and serotonin 5-HT1A-receptor affinities

Authors
Feenstra, RW de Moes, J Hofma, JJ Kling, H Kuipers, W Long, SK Tulp, MTM van der Heyden, JAM Kruse, CG
Citation
Rw. Feenstra et al., New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D-2-receptor and serotonin 5-HT1A-receptor affinities, BIOORG MED, 11(17), 2001, pp. 2345-2349
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
17
Year of publication
2001
Pages
2345 - 2349
Database
ISI
SICI code
0960-894X(20010903)11:17<2345:N1APAA>2.0.ZU;2-4
Abstract
This paper describes the syntheses of several 1-aryl-4-(biarylmethylene)pip erazines and the results of the determination of their affinity for D-2 and 5-HT1A receptors. A selection of these compounds was evaluated in vivo, re sulting in the identification of a drug candidate which is being clinically evaluated as a potential atypical antipsychotic with reduced extrapyrimida l side effects. (C) 2001 Elsevier Science Ltd. All rights reserved.