Hydrolysis of plasmid DNA catalyzed by Co(III) complex of cyclen attached to polystyrene

Authors
Jeung, CS Kim, CH Min, K Suh, SW Suh, J
Citation
Cs. Jeung et al., Hydrolysis of plasmid DNA catalyzed by Co(III) complex of cyclen attached to polystyrene, BIOORG MED, 11(17), 2001, pp. 2401-2404
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
17
Year of publication
2001
Pages
2401 - 2404
Database
ISI
SICI code
0960-894X(20010903)11:17<2401:HOPDCB>2.0.ZU;2-9
Abstract
Reactivity of the Co(III) complex of cyclen (CoCyc) in the hydrolytic cleav age of supercoiled pUC18 DNA leading to the formation of the corresponding open circular form was enhanced by > 200 times upon attachment of CoCyc to cross-linked polystyrenes. Thus, half-lives as short as 40 min were achieve d by the resin-based CoCyc in cleavage of the supercoiled DNA Lit 4 degrees C. (C) 2001 Elsevier Science Ltd. All rights reserved.