GENE-TRANSFER STRATEGIES FOR AUGMENTING CARDIAC-FUNCTION

Recent transgenic as well as gene-targeted animal models have greatly increased our understanding of the molecular mechanisms of normal and compromised heart function. These studies have raised the possibility of using somatic gene transfer as a means for improving cardiac functi on. DNA transfer to a significant portion of the myocardium has thus f ar been difficult to accomplish. This review describes current efforts to achieve myocardial gene transfer in several model systems, with pa rticular emphasis placed on adenovirus-mediated gene delivery, its pos sibilities, and current limitations. (C) 1997, Elsevier Science Inc.