Therapy-related refractory anemia with ringed sideroblasts in chronic lymphocytic leukemia: involvement of 3q21 region

Authors
Yagci, M Sucak, GT Ogur, G Haznedar, R
Citation
M. Yagci et al., Therapy-related refractory anemia with ringed sideroblasts in chronic lymphocytic leukemia: involvement of 3q21 region, CANC GENET, 129(1), 2001, pp. 43-46
Citations number
28
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
129
Issue
1
Year of publication
2001
Pages
43 - 46
Database
ISI
SICI code
0165-4608(200108)129:1<43:TRAWRS>2.0.ZU;2-C
Abstract
Therapy-related myelodysplastic syndrome/acute myelogenous leukemia (t-MDS/ AML) is extremely rare in chronic lymphocytic leukemia (CLL) despite extens ive use of alkylating agents. We present a case of heavily treated CLL with resultant therapy-related refractory anemia with ringed sideroblasts (RARS ). A complex cytogenetic abnormality including involvement of 3q21 was dete cted and to our knowledge, is the first report of a RARS case with a 3q21 a bnormality. (C) 2001 Elsevier Science Inc. All rights reserved.