Comparative genomic hybridization reveals non-random chromosomal aberrations in early preinvasive cervical lesions

We performed CGH analysis on 34 cervical lesions, which included 8 cases of koilocytosis, 6 mild dysplasias and 20 moderate dysplasias. Chromosome abe rrations were detected in 1 cases of which 9 were moderate dysplasias. A to tal of 55 chromosome arms were involved. The most frequent aberrations were losses of 5p and Xq, each of which was present in 5/34 cases. Gain of 3q w as detected in two moderate dysplasias. This aberration is the most frequen t copy number change in advanced-stage cervical carcinoma. A considerable n umber of the aberrations found in the preinvasive cases of this study are f requently present in invasive cervical tumors. The presence of apparently n on-random chromosome aberrations in early preinvasive cervical lesions has not previously been described. (C) 2001 Elsevier Science Inc. All rights re served.