Resveratrol and quercetin inhibit angiogenesis in vitro

Resveratrol and quercetin are polyphenolic compounds found in grapes, red w ine and other food products. In this study, we examined the effect of resve ratrol and quercetin on the inhibition of angiogenesis in vitro. Resveratro l and quercetin inhibited the growth of bovine aorta endothelial (BAE) cell s in a concentration-dependent manner (6-100 muM). The migration of BAE was obviously inhibited by resveratrol and weakly inhibited by quercetin. When the lengths of all tubes constructed in the 3-D culture system with or wit hout resveratrol or quercetin were measured, resveratrol was found to inhib it the tube formation of BAE cells in a concentration-dependent manner (6-1 00 muM). On the other hand, quercetin at concentrations above 100_M signifi cantly inhibited the tube formation of vascular endothelial cells. From the se results, we suggest that resveratrol and quercetin may prove useful in t he development of useful therapeutic agents or preventive food factors for tumor angiogenesis. (C) 2001 Published by Elsevier Science Ireland Ltd.