Expression of p21(WAF1/CIP1) and p53 proteins in gastric carcinoma: its relationships with cell proliferation activity and prognosis

Citation
Xp. Liu et al., Expression of p21(WAF1/CIP1) and p53 proteins in gastric carcinoma: its relationships with cell proliferation activity and prognosis, CANCER LETT, 170(2), 2001, pp. 183-189
Citations number
33
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
03043835 → ACNP
Volume
170
Issue
2
Year of publication
2001
Pages
183 - 189
Database
ISI
SICI code
0304-3835(20010920)170:2<183:EOPAPP>2.0.ZU;2-X
Abstract
The expressions of p21(WAF1/CIP1), p53 proteins, and Ki-67 antigen were inv estigated immunohistochemic ally in 190 primary gastric carcinomas. Of the 190 tumors, 40.5% positively expressed p21(WAF1/CIP1) and 42.1% positively expressed p53. The expression of p21(WAF1/CIP1) was significantly associate d with clinicopathological factors including gender, tumor size, status of lymph node, and clinicopathological stage (P < 0.05 for all), but p21(WAF1/ CIP1) expression showed no clear correlation with Ki-67 labeling index. The mean Ki-67 labeling index was significantly higher in p53-positive cases t han p53-negative, cases (P < 0.0001). However, among the clinicopathologica l factors examined, expression of p53 correlated only with age. Univariate and multivariate survival analyses revealed that clinicopathological stage (P < 0.001) and expression status of p21(WAF1/CIP1) (P < 0.05) were indepen dent prognostic factors. Neither the expression status of p53 nor the Ki-67 labeling index, however, influenced the prognosis of patients with gastric cancer. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.