Xp. Liu et al., Expression of p21(WAF1/CIP1) and p53 proteins in gastric carcinoma: its relationships with cell proliferation activity and prognosis, CANCER LETT, 170(2), 2001, pp. 183-189
The expressions of p21(WAF1/CIP1), p53 proteins, and Ki-67 antigen were inv
estigated immunohistochemic ally in 190 primary gastric carcinomas. Of the
190 tumors, 40.5% positively expressed p21(WAF1/CIP1) and 42.1% positively
expressed p53. The expression of p21(WAF1/CIP1) was significantly associate
d with clinicopathological factors including gender, tumor size, status of
lymph node, and clinicopathological stage (P < 0.05 for all), but p21(WAF1/
CIP1) expression showed no clear correlation with Ki-67 labeling index. The
mean Ki-67 labeling index was significantly higher in p53-positive cases t
han p53-negative, cases (P < 0.0001). However, among the clinicopathologica
l factors examined, expression of p53 correlated only with age. Univariate
and multivariate survival analyses revealed that clinicopathological stage
(P < 0.001) and expression status of p21(WAF1/CIP1) (P < 0.05) were indepen
dent prognostic factors. Neither the expression status of p53 nor the Ki-67
labeling index, however, influenced the prognosis of patients with gastric
cancer. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.