Linear fluorescent oligonucleotide probes with an acridine quencher generate a signal upon hybridisation

Authors
Ranasinghe, RT Brown, LJ Brown, T
Citation
Rt. Ranasinghe et al., Linear fluorescent oligonucleotide probes with an acridine quencher generate a signal upon hybridisation, CHEM COMMUN, (16), 2001, pp. 1480-1481
Citations number
12
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
16
Year of publication
2001
Pages
1480 - 1481
Database
ISI
SICI code
1359-7345(20010821):16<1480:LFOPWA>2.0.ZU;2-2
Abstract
Linear, single stranded probes incorporating a fluorophore and an acridine moiety are weakly fluorescent until hybridised to a complementary target nu cleic acid whereupon fluorescence increases due to reduced quenching.