Studies of applications of a new matrix - alpha-cyano ferulic acid in MALDI-TOFMS

This paper reports for the first time an experiment designed in which synth esized alpha -cyano ferulic acid used as a new matrix for the analysis of c ytochrome c, trypsin, bovine serum albumin, beta -cyclodextrin, dextrans an d DNA d(T)(18). The results demonstrated that alpha -cyano ferulic acid use d as a new matrix could effectively desorb and ionize different kinds of sa mples, such as proteins and peptides, oligosaccharides, polysaccharides and oligonucleotides. In analysis of dextrans the new matrix gave better resul ts when comparing with the normally used DHB. In analysis of DNA d(T)(18), the sample could be desorbed and ionized more efficiently even without samp le purification, which is normally needed when using 3-HPA as a matrix.