Synthesis and conformational study of Schiff bases derived from o-vanillinand amino acids

Four Schiff bases derived from o-vanillin and amino acids have been synthes ized and characterized by elemental analysis and IR. The conformations of f our Schiff bases have been studied using molecular dynamics and quantum che mistry analysis approaches. The results revealed that the trans C - N with R configuration of the title compounds are more stable than their S configu ration and there was a negative charge hole in the Schiff base, which shows the high possibility of forming stable complexe because metal ion is easy to enter this negative charge hole.