SUPPRESSION OF FRANCISELLA-TULARENSIS GROWTH IN THE RAT BY COINFECTION WITH F-NOVICIDA

Authors
COWLEY SC MYLTSEVA SV NANO FE
Citation
Sc. Cowley et al., SUPPRESSION OF FRANCISELLA-TULARENSIS GROWTH IN THE RAT BY COINFECTION WITH F-NOVICIDA, FEMS microbiology letters, 153(1), 1997, pp. 71-74
Citations number
18
Categorie Soggetti
Microbiology
Journal title
FEMS microbiology letters → ACNP
ISSN journal
03781097
Volume
153
Issue
1
Year of publication
1997
Pages
71 - 74
Database
ISI
SICI code
0378-1097(1997)153:1<71:SOFGIT>2.0.ZU;2-N
Abstract
We have previously shown that when cultured in vitro, peritoneal rat m acrophages infected with Francisella novicida spontaneously release ni tric oxide in sufficient quantities to inhibit bacterial growth. Howev er, it is not known whether F, novicida can have a similar antimicrobi al effect in vivo. Here we show that a co-infection of F. novicida wit h Francisella tularensis can suppress the number of F. tularensis cell s in rat spleens by as much as 100-fold.