K. Knudsen et B. Lisander, METOCLOPRAMIDE DECREASES EMESIS AFTER SPINAL-ANESTHESIA SUPPLEMENTED WITH SUBARACHNOID MORPHINE, Regional anesthesia, 19(6), 1994, pp. 390-394
Background and Objectives. The authors studied whether metoclopramide
decreases the incidence of emesis after spinal anesthesia supplemented
with subarachnoid morphine. Methods. Patients underwent total hip art
hroplasty under spinal anesthesia using tetracaine with norepinephrine
and morphine 0.2 mg. Forty-eight patients were included in the study
conducted with a paired design, using sequential analysis. Patients we
re allocated randomly and double-blinded to the treatment with metoclo
pramide or to the control group. In one group, metoclopramide 20 mg in
tramuscularly was given before and after surgery; patients in the cont
rol group were given equal volumes of saline. The presence of emesis f
or 5 hours postoperatively was recorded. Results. In the postoperative
period, emesis was noted in 58% of control patients but in only 17% o
f patients given metoclopramide (P < .05). Conclusions. The data sugge
st that metoclopramide is effective against postoperative emesis after
spinal anesthesia supplemented with subarachnoid morphine.