Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3)

Citation
B. Dechairo et al., Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3), EUR J HUM G, 9(8), 2001, pp. 627-633
Citations number
53
Categorie Soggetti
Molecular Biology & Genetics
Journal title
EUROPEAN JOURNAL OF HUMAN GENETICS
ISSN journal
10184813 → ACNP
Volume
9
Issue
8
Year of publication
2001
Pages
627 - 633
Database
ISI
SICI code
1018-4813(200108)9:8<627:RAESOI>2.0.ZU;2-R
Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the i ntestine, commonly diagnosed as either ulcerative colitis (UB) or Crohn's d isease (CD). Epidemiological studies have consistently shown that both gene tic and environmental factors influence the pathogenesis of IBD. A number o f genome scans have been conducted in cohorts of IBD families with affected sibling pairs (ASPs) to identify chromosomal regions that harbour IBD susc eptibility genes. Several putative linked loci have been identified, includ ing two loci on chromosomes 16 and 12, IBD1 and IBD2, which have subsequent ly been replicated by independent region-specific studies. We have conducte d both a replication study on another linkage region, chromosome 6p (IBD3), and extension studies on two other regions, chromosomes 3p and 7q. Microsa tellite markers across each region were genotyped in 284 IBD ASPs from 234 families. A nonparametric peak multipoint LOD score of 3.0 was observed nea r D6S291, replicating the previous linkage to chromosome 6p (IBD3). Nominal evidence of linkage was observed at both the 3p and 7q regions.