Histopathologic diagnosis of malignant lymphomas based on classification of World Health Organization

The principles of the diagnosis of malignant lymphomas in accordance with n ew WHO classification have been considered. The histopathologic criteria pr ovide for 80-95% reproducibility in the diagnosis of the different lymphoma entities. Immunohistochemistry with a large panel of monoclonal antibodies to differentiate lymphomas of B-, T- and NK-cell origin should be done ste p by step when necessary. The criteria used to delineate lymphomas originat ing from lymphoid precursor cells and mature (peripheral) lymphocytes have been treated in details. Small B-cell lymphomas, B-CLL, mantle cell lymphom a, marginal zone lymphoma, follicular lymphoma, lymphoplasmacytic lymphoma, large B-cell lymphomas, Burkitt's lymphoma, T-cell lymphoma, Hodgkin's lym phoma have been characterized on the basis of their histomorphology and imm unophenotyping.