Escherichia coli cytotoxic necrotizing factor and Pasteurella multocida toxin induce focal adhesion kinase autophosphorylation and Src association

Authors
Thomas, W Pullinger, GD Lax, AJ Rozengurt, E
Citation
W. Thomas et al., Escherichia coli cytotoxic necrotizing factor and Pasteurella multocida toxin induce focal adhesion kinase autophosphorylation and Src association, INFEC IMMUN, 69(9), 2001, pp. 5931-5935
Citations number
55
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
9
Year of publication
2001
Pages
5931 - 5935
Database
ISI
SICI code
0019-9567(200109)69:9<5931:ECCNFA>2.0.ZU;2-A
Abstract
Cytotoxic necrotizing factor 1 and Pasteurella multocida toxin induced dose - and time-dependent increases in focal adhesion kinase (FAK) Tyr(397) phos phorylation in Swiss 3T3 cells. FAK autophosphorylation was sensitive to in hibitors of p160/ROCK and coincided with the formation of stable complexes between FAK and Src family members.