Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice

Authors
Lauw, FN Florquin, S Speelman, P van Deventer, SJH van der Poll, T
Citation
Fn. Lauw et al., Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice, INFEC IMMUN, 69(9), 2001, pp. 5949-5952
Citations number
22
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
9
Year of publication
2001
Pages
5949 - 5952
Database
ISI
SICI code
0019-9567(200109)69:9<5949:ROEIII>2.0.ZU;2-A
Abstract
In the present study, the roles of interleukin 12 (IL-12) and IL-18 and the ir possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data su ggest that the role of IL-12 in SEB-induced responses is limited to sustain ing gamma interferon release by an IL-18-independent mechanism.