PcrV immunization enhances survival of burned Pseudomonas aeruginosa-infected mice

Authors
Holder, IA Neely, AN Frank, DW
Citation
Ia. Holder et al., PcrV immunization enhances survival of burned Pseudomonas aeruginosa-infected mice, INFEC IMMUN, 69(9), 2001, pp. 5908-5910
Citations number
14
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
9
Year of publication
2001
Pages
5908 - 5910
Database
ISI
SICI code
0019-9567(200109)69:9<5908:PIESOB>2.0.ZU;2-S
Abstract
Burned Pseudomonas aeruginosa-infected mice immunized against PcrV, a type III virulence system translocating protein, showed significantly enhanced s urvival compared to controls. Survival was non-O serotype specific and corr elated with a reduced systemic microbial load. Infection with a high-level toxin A-producing strain required supplemental antitoxin treatment to enhan ce survival.