Metachromasia of the endocervical epithelium in women treated with gonadotropin releasing hormone agonist

Endocervical epithelium from women treated with gonadotropin releasing horm one agonist (GnRH agonist) were compared with those from untreated women, u sing metachromatic stain with toluidine blue and immunohistochemistry, for estrogen and progesterone receptors. Smaller endocervical epithelium with l ower intraepithelial mucus and more prominent nuclear distribution of estro gen receptors were seen in a woman who was treated for twelve months with G nRH agonists, as compared with those from an untreated premenopausal woman.