Age-related decrease in calcitonin gene-related peptide mRNA in the dorsalroot ganglia of spontaneously hypertensive rats

Authors
Yamaga, N Kawasaki, H Inaizumi, K Shimizu, M Nakamura, A Kurosaki, Y
Citation
N. Yamaga et al., Age-related decrease in calcitonin gene-related peptide mRNA in the dorsalroot ganglia of spontaneously hypertensive rats, JPN J PHARM, 86(4), 2001, pp. 448-450
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JAPANESE JOURNAL OF PHARMACOLOGY
ISSN journal
00215198 → ACNP
Volume
86
Issue
4
Year of publication
2001
Pages
448 - 450
Database
ISI
SICI code
0021-5198(200108)86:4<448:ADICGP>2.0.ZU;2-O
Abstract
Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRN A of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontan eously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto ra ts (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The co ntents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These result s suggest that the outflow of CGRP-containing nerves from the spinal cord a nd CGRP release from CGRP nerve terminals decreases in SHR.