Early binocular visual experience may improve binocular sensory outcomes in children after surgery for congenital unilateral cataract

Purpose: To compare the effect of intensive and reduced occlusion therapy r egimens on binocular sensory outcomes, visual acuity, and the prevalence of strabismus in children after surgery for congenital unilateral cataract. M ethods:Two nonrandomized groups of patients were studied prospectively: (1) an intensive occlusion group (n = 29) patched 80% of waking hours were fol lowed for a median 6.9 years and (2) a reduced occlusion group (n = 8) patc hed 25% to 50% of waking hours were followed for a median 4.3 years. Six su bjects in the intensive group and 4 in the reduced occlusion group had seco ndary intraocular lenses. Two subjects in the intensive group had epikerato phakia surgery. Binocular sensory function was assessed with random dot and contour stereoacuity tests and the Worth 4-dot test. The prevalence and ag e at onset of strabismus were determined from the patients' charts. Results . A higher proportion of subjects in the reduced occlusion group (50%) had stereoacuity or fusion compared with the intensive occlusion group (14%), a borderline significant difference (P=.08). No significant difference (P=.5 5) was found in median visual acuity between the intensive (20/50) and the reduced occlusion (20/55) groups. The 90% prevalence of strabismus in the i ntensive occlusion group was slightly higher than the 63% prevalence in the reduced occlusion group, although this difference was not significant (P=. 18). Conclusions: These results suggest that a reduced occlusion protocol m ay be associated with better binocular sensory outcomes and a reduced preva lence of strabismus without compromising good visual acuity in children tre ated for congenital unilateral cataract.