Hypervalent iodine compounds as potent antibacterial agents against ice nucleation active (INA) Pseudomonas syringae

Twenty-three hypervalent iodine compounds belonging to aryliodonium salts, 1, aryliodonium ylides, 2, and (diacyloxyiodo)arenes, 3, were tested for th eir antibacterial activities against ice nucleation active (INA) Pseudomona s syringae, and the MIC and EC50 values were determined. All of the compoun ds examined caused a dose-dependent decrease in bacterial growth rates. Ary liodonium salts, especially those with electron-withdrawing groups, exhibit higher antibacterial activities with MIC = 8-16 ppm, whereas the nature of the anion does not seem to affect the activities of the diaryliodonium sal ts.