STUDIES ON ANALGESIC AND ANTIINFLAMMATORY ACTIVITIES OF 1-DIALKYLAMINOMETHYL-2-(P-SUBSTITUTED PHENYL)-5-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

In this study the analgesic and anti-inflammatory activity of 1,2,5-tr isubstituted benzimidazole derivatives have been examined. Analgesic a ctivities of these compounds were investigated by using the modified K oster test. Among the compounds synthesized especially compound 1g (1- diethylaminomethyl)-2-(p-chlorophenyl)-5-nitro benzimidazole hydrochlo ride) has shown higher activity than acetylsalicylic acid (ASA) and in dometacin. Compound 1e 1-(diethylaminomethyl)-2-(p-methoxyphenyl)-5-ni tro benzimidazole hydrochloride, 1f (1-(diethylaminomethyl)-2-(p-tolyl )-5-nitro benzimidazole hydrochloride and 1i (1-(pipenridinomethyl)-2- (p-methoxyphenyl)-5-nitro benzimidazole hydrochloride) proved as poten t as the standard ASA. Therefore the compounds 1e, 1f, 1g and 1i were screened for their anti-inflammatory activities using the carrageenan- induced hind paw edema test. Except 1g all compounds were almost inact ive against this model of inflammation compared to indometacin.