INTRACELLULAR ACTIVITY OF AZITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM COMPLEX IN HUMAN MACROPHAGES

Authors
WILDFEUER A HABERREITER A
Citation
A. Wildfeuer et A. Haberreiter, INTRACELLULAR ACTIVITY OF AZITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM COMPLEX IN HUMAN MACROPHAGES, Arzneimittel-Forschung, 47(7), 1997, pp. 866-868
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
47
Issue
7
Year of publication
1997
Pages
866 - 868
Database
ISI
SICI code
0004-4172(1997)47:7<866:IAOAAM>2.0.ZU;2-J
Abstract
In the concentration range examined (0.5-16 mu g/ml) the azalide antib iotic azithromycin (CAS 83905-01-5, Zithromax(R)) inhibited the growth of mycobacteria in macrophages over 7 days. The higher concentrations of azithromycin, 8 and 16 mu g/ml, reduced the number of phagocytized bacteria in macrophages by at least 1 log unit within 4 days. The sys tem used, macrophages from healthy volunteers, is suitable for testing the intracellular activity of drugs against the Mycobacterium avium c omplex.